abstract：:An "off-the-shelf" cell therapy derived from induced pluripotent stem cells (iPSCs) has entered clinical trials in the United States. Other companies are following suit, harnessing iPSCs' self-renewal ability to manufacture cell therapies that don't require customization for each patient. But some experts aren't sure ...

journal_title：Cell

authors： Crow D

更新日期：2019-06-13 00:00:00

abstract：:Ebola virus (EBOV) remains a public health threat. We performed a longitudinal study of B cell responses to EBOV in four survivors of the 2014 West African outbreak. Infection induced lasting EBOV-specific immunoglobulin G (IgG) antibodies, but their subclass composition changed over time, with IgG1 persisting, IgG3 r...

journal_title：Cell

authors： Davis CW,Jackson KJL,McElroy AK,Halfmann P,Huang J,Chennareddy C,Piper AE,Leung Y,Albariño CG,Crozier I,Ellebedy AH,Sidney J,Sette A,Yu T,Nielsen SCA,Goff AJ,Spiropoulou CF,Saphire EO,Cavet G,Kawaoka Y,Mehta AK,

更新日期：2019-05-30 00:00:00

abstract：:Metabolic coordination between neurons and astrocytes is critical for the health of the brain. However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural activity, remains largely uncharacterized. Here, we demonstrate that toxic fatty acids (FAs) produced in hyperactive neurons are tran...

journal_title：Cell

authors： Ioannou MS,Jackson J,Sheu SH,Chang CL,Weigel AV,Liu H,Pasolli HA,Xu CS,Pang S,Matthies D,Hess HF,Lippincott-Schwartz J,Liu Z

更新日期：2019-05-30 00:00:00

abstract：:Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond inde...

journal_title：Cell

authors： Welz PS,Zinna VM,Symeonidi A,Koronowski KB,Kinouchi K,Smith JG,Guillén IM,Castellanos A,Furrow S,Aragón F,Crainiciuc G,Prats N,Caballero JM,Hidalgo A,Sassone-Corsi P,Benitah SA

更新日期：2019-05-30 00:00:00

abstract：:The crystal structure of the β2-adrenergic receptor (β2AR) bound to the G protein adenylyl cyclase stimulatory G protein (Gs) captured the complex in a nucleotide-free state (β2AR-Gsempty). Unfortunately, the β2AR-Gsempty complex does not provide a clear explanation for G protein coupling specificity. Evidence from se...

journal_title：Cell

authors： Liu X,Xu X,Hilger D,Aschauer P,Tiemann JKS,Du Y,Liu H,Hirata K,Sun X,Guixà-González R,Mathiesen JM,Hildebrand PW,Kobilka BK

更新日期：2019-05-16 00:00:00

abstract：:The intestinal microbiota produces tens of thousands of metabolites. Here, we used host sensing of small molecules by G-protein coupled receptors (GPCRs) as a lens to illuminate bioactive microbial metabolites that impact host physiology. We screened 144 human gut bacteria against the non-olfactory GPCRome and identif...

journal_title：Cell

authors： Chen H,Nwe PK,Yang Y,Rosen CE,Bielecka AA,Kuchroo M,Cline GW,Kruse AC,Ring AM,Crawford JM,Palm NW

更新日期：2019-05-16 00:00:00

abstract：:Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets ...

journal_title：Cell

authors： Romanov N,Kuhn M,Aebersold R,Ori A,Beck M,Bork P

更新日期：2019-05-16 00:00:00

abstract：:Prolonged behavioral challenges can cause animals to switch from active to passive coping strategies to manage effort-expenditure during stress; such normally adaptive behavioral state transitions can become maladaptive in psychiatric disorders such as depression. The underlying neuronal dynamics and brainwide interac...

journal_title：Cell

authors： Andalman AS,Burns VM,Lovett-Barron M,Broxton M,Poole B,Yang SJ,Grosenick L,Lerner TN,Chen R,Benster T,Mourrain P,Levoy M,Rajan K,Deisseroth K

更新日期：2019-05-02 00:00:00

abstract：:In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell "macrolesions" are characteristically pro-inflammatory, resident macrophages can "cloak" single-cell micro...

journal_title：Cell

authors： Blériot C,Ng LG,Ginhoux F

更新日期：2019-04-18 00:00:00

abstract：:New neurons arise from quiescent adult neural progenitors throughout life in specific regions of the mammalian brain. Little is known about the embryonic origin and establishment of adult neural progenitors. Here, we show that Hopx+ precursors in the mouse dentate neuroepithelium at embryonic day 11.5 give rise to pro...

journal_title：Cell

authors： Berg DA,Su Y,Jimenez-Cyrus D,Patel A,Huang N,Morizet D,Lee S,Shah R,Ringeling FR,Jain R,Epstein JA,Wu QF,Canzar S,Ming GL,Song H,Bond AM

更新日期：2019-04-18 00:00:00

abstract：:Insulin receptor (IR) signaling is central to normal metabolic control and dysregulated in prevalent chronic diseases. IR binds insulin at the cell surface and transduces rapid signaling via cytoplasmic kinases. However, mechanisms mediating long-term effects of insulin remain unclear. Here, we show that IR associates...

journal_title：Cell

authors： Hancock ML,Meyer RC,Mistry M,Khetani RS,Wagschal A,Shin T,Ho Sui SJ,Näär AM,Flanagan JG

更新日期：2019-04-18 00:00:00

abstract：:Yeast ataxin-2, also known as Pbp1 (polyA binding protein-binding protein 1), is an intrinsically disordered protein implicated in stress granule formation, RNA biology, and neurodegenerative disease. To understand the endogenous function of this protein, we identify Pbp1 as a dedicated regulator of TORC1 signaling an...

journal_title：Cell

authors： Yang YS,Kato M,Wu X,Litsios A,Sutter BM,Wang Y,Hsu CH,Wood NE,Lemoff A,Mirzaei H,Heinemann M,Tu BP

更新日期：2019-04-18 00:00:00

abstract：:The heterogeneity of small extracellular vesicles and presence of non-vesicular extracellular matter have led to debate about contents and functional properties of exosomes. Here, we employ high-resolution density gradient fractionation and direct immunoaffinity capture to precisely characterize the RNA, DNA, and prot...

journal_title：Cell

authors： Jeppesen DK,Fenix AM,Franklin JL,Higginbotham JN,Zhang Q,Zimmerman LJ,Liebler DC,Ping J,Liu Q,Evans R,Fissell WH,Patton JG,Rome LH,Burnette DT,Coffey RJ

更新日期：2019-04-04 00:00:00

abstract：:Affordable genome sequencing technologies promise to revolutionize the field of human genetics by enabling comprehensive studies that interrogate all classes of genome variation, genome-wide, across the entire allele frequency spectrum. Ongoing projects worldwide are sequencing many thousands-and soon millions-of huma...

journal_title：Cell

authors： Lappalainen T,Scott AJ,Brandt M,Hall IM

更新日期：2019-03-21 00:00:00

abstract：:The promise of human genetics and genomics is nothing less than a fully tailored life, starting with medical treatments, diets, and preventative care all styled around a single genome. There's a lighter side as well where consumer genomics companies are helping people understand themselves and their families. Lara Sze...

journal_title：Cell

authors：

更新日期：2019-03-21 00:00:00

abstract：:In this issue, Marcandalli et al. (2019) report a self-assembling nanoparticle bearing an antigen from respiratory syncytial virus. This is the first time the structure, stability, and adjuvanticity of an antigen have been rationally designed at the atomic level and incorporated in one vaccine. ...

journal_title：Cell

authors： Rappuoli R,Serruto D

更新日期：2019-03-07 00:00:00

abstract：:The function of somatic stem cells declines with age. Understanding the molecular underpinnings of this decline is key to counteract age-related disease. Here, we report a dramatic drop in the neural stem cells (NSCs) number in the aging murine brain. We find that this smaller stem cell reservoir is protected from ful...

journal_title：Cell

authors： Kalamakis G,Brüne D,Ravichandran S,Bolz J,Fan W,Ziebell F,Stiehl T,Catalá-Martinez F,Kupke J,Zhao S,Llorens-Bobadilla E,Bauer K,Limpert S,Berger B,Christen U,Schmezer P,Mallm JP,Berninger B,Anders S,Del Sol A,Marc

更新日期：2019-03-07 00:00:00

abstract：:The specific patterns and functional properties of electrical synapses of a nervous system are defined by the neuron-specific complement of electrical synapse constituents. We systematically examined the molecular composition of the electrical connectome of the nematode C. elegans through a genome- and nervous-system-...

journal_title：Cell

authors： Bhattacharya A,Aghayeva U,Berghoff EG,Hobert O

更新日期：2019-02-21 00:00:00

abstract：:Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomen...

journal_title：Cell

authors： Tucci V,Isles AR,Kelsey G,Ferguson-Smith AC,Erice Imprinting Group.

更新日期：2019-02-21 00:00:00

abstract：:Through dissecting the link between spatial genome organization and DNA replication timing, Sima et al. (2018) discover early replicating control elements (ERCEs), a new type of cis-acting elements that regulate replication timing, transcription, and multiple layers of three-dimensional features of genome organization...

journal_title：Cell

authors： Ma J,Duan Z

更新日期：2019-02-07 00:00:00

abstract：:In developing organisms, spatially prescribed cell identities are thought to be determined by the expression levels of multiple genes. Quantitative tests of this idea, however, require a theoretical framework capable of exposing the rules and precision of cell specification over developmental time. We use the gap gene...

journal_title：Cell

authors： Petkova MD,Tkačik G,Bialek W,Wieschaus EF,Gregor T

更新日期：2019-02-07 00:00:00

abstract：:Elucidating the global and local rules that govern genome-wide, hierarchical chromatin architecture remains a critical challenge. Current high-throughput chromosome conformation capture (Hi-C) technologies have identified large-scale chromatin structural motifs, such as topologically associating domains and looping. H...

journal_title：Cell

authors： Ohno M,Ando T,Priest DG,Kumar V,Yoshida Y,Taniguchi Y

更新日期：2019-01-24 00:00:00

abstract：:Evidence is now mounting that liquid-liquid phase separation (LLPS) underlies the formation of membraneless compartments in cells. This realization has motivated major efforts to delineate the function of such biomolecular condensates in normal cells and their roles in contexts ranging from development to age-related ...

journal_title：Cell

authors： Alberti S,Gladfelter A,Mittag T

更新日期：2019-01-24 00:00:00

abstract：:Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to increase translational output and promote tumorigenesis in vivo. ME...

journal_title：Cell

authors： Liu S,Hausmann S,Carlson SM,Fuentes ME,Francis JW,Pillai R,Lofgren SM,Hulea L,Tandoc K,Lu J,Li A,Nguyen ND,Caporicci M,Kim MP,Maitra A,Wang H,Wistuba II,Porco JA Jr,Bassik MC,Elias JE,Song J,Topisirovic I,Van

更新日期：2019-01-24 00:00:00

abstract：:The angiotensin II (AngII) type 1 receptor (AT1R) is a critical regulator of cardiovascular and renal function and is an important model for studies of G-protein-coupled receptor (GPCR) signaling. By stabilizing the receptor with a single-domain antibody fragment ("nanobody") discovered using a synthetic yeast-display...

journal_title：Cell

authors： Wingler LM,McMahon C,Staus DP,Lefkowitz RJ,Kruse AC

更新日期：2019-01-24 00:00:00

abstract：:Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received...

journal_title：Cell

authors： Gibson EM,Nagaraja S,Ocampo A,Tam LT,Wood LS,Pallegar PN,Greene JJ,Geraghty AC,Goldstein AK,Ni L,Woo PJ,Barres BA,Liddelow S,Vogel H,Monje M

更新日期：2019-01-10 00:00:00

abstract：:During development, the precise relationships between transcription and chromatin modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm to explore the implication of chromatin changes in gene silencing. Using female mouse embryonic stem cells, we initiate XCI by inducing Xist and then...

journal_title：Cell

authors： Żylicz JJ,Bousard A,Žumer K,Dossin F,Mohammad E,da Rocha ST,Schwalb B,Syx L,Dingli F,Loew D,Cramer P,Heard E

更新日期：2019-01-10 00:00:00

abstract：:Csm, a type III-A CRISPR-Cas interference complex, is a CRISPR RNA (crRNA)-guided RNase that also possesses target RNA-dependent DNase and cyclic oligoadenylate (cOA) synthetase activities. However, the structural features allowing target RNA-binding-dependent activation of DNA cleavage and cOA generation remain unkno...

journal_title：Cell

authors： You L,Ma J,Wang J,Artamonova D,Wang M,Liu L,Xiang H,Severinov K,Zhang X,Wang Y

更新日期：2019-01-10 00:00:00

abstract：:Phages must be perfectly attuned to bacterial host cell physiology to ensure their optimal survival. Silpe and Bassler show that a Vibrio phage uses the host quorum-sensing pathway to trigger production of viral progeny at high cell density. ...

journal_title：Cell

authors： Maxwell KL

更新日期：2019-01-10 00:00:00

abstract：:During the postpartum period, the brain's inhibitory GABAA receptors may not recover in time following their reduced numbers during pregnancy. This is likely the cause of postpartum depression prevalent in ∼12% of childbearing women. A new therapy for this condition consists of administering a synthetic neurosteroid d...

journal_title：Cell

authors： Mody I

更新日期：2019-01-10 00:00:00

abstract：:Mosquito-borne flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), are a growing public health concern. Systems-level analysis of how flaviviruses hijack cellular processes through virus-host protein-protein interactions (PPIs) provides information about their replication and pathogenic mechanisms. We u...

journal_title：Cell

authors： Shah PS,Link N,Jang GM,Sharp PP,Zhu T,Swaney DL,Johnson JR,Von Dollen J,Ramage HR,Satkamp L,Newton B,Hüttenhain R,Petit MJ,Baum T,Everitt A,Laufman O,Tassetto M,Shales M,Stevenson E,Iglesias GN,Shokat L,Tripathi

更新日期：2018-12-13 00:00:00

abstract：:Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (CLR + RAMP1) offer considerable improvements over existing drugs in migraine prophylaxis and are the first designed to act on the trigeminal pain system. Erenumab is approved by the FDA and EMA and has reached the market since May 20...

journal_title：Cell

authors： Edvinsson L

更新日期：2018-12-13 00:00:00

abstract：:The fluid-mosaic model posits a liquid-like plasma membrane, which can flow in response to tension gradients. It is widely assumed that membrane flow transmits local changes in membrane tension across the cell in milliseconds, mediating long-range signaling. Here, we show that propagation of membrane tension occurs qu...

journal_title：Cell

authors： Shi Z,Graber ZT,Baumgart T,Stone HA,Cohen AE

更新日期：2018-12-13 00:00:00

abstract：:During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage tracing, we studied whether murine dermal fibroblasts are altered during physiological aging under different di...

journal_title：Cell

authors： Salzer MC,Lafzi A,Berenguer-Llergo A,Youssif C,Castellanos A,Solanas G,Peixoto FO,Stephan-Otto Attolini C,Prats N,Aguilera M,Martín-Caballero J,Heyn H,Benitah SA

更新日期：2018-11-29 00:00:00

abstract：:The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequentially induces satiation, thereby establishing a gut-secretin-BAT-brain a...

journal_title：Cell

authors： Li Y,Schnabl K,Gabler SM,Willershäuser M,Reber J,Karlas A,Laurila S,Lahesmaa M,U Din M,Bast-Habersbrunner A,Virtanen KA,Fromme T,Bolze F,O'Farrell LS,Alsina-Fernandez J,Coskun T,Ntziachristos V,Nuutila P,Klingenspor M

更新日期：2018-11-29 00:00:00

abstract：:The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a ne...

journal_title：Cell

authors： Welsh TJ,Shen Y,Levin A,Knowles TPJ

更新日期：2018-11-29 00:00:00

abstract：:In eukaryotic cells, organelles and the cytoskeleton undergo highly dynamic yet organized interactions capable of orchestrating complex cellular functions. Visualizing these interactions requires noninvasive, long-duration imaging of the intracellular environment at high spatiotemporal resolution and low background. T...

journal_title：Cell

authors： Guo Y,Li D,Zhang S,Yang Y,Liu JJ,Wang X,Liu C,Milkie DE,Moore RP,Tulu US,Kiehart DP,Hu J,Lippincott-Schwartz J,Betzig E,Li D

更新日期：2018-11-15 00:00:00

abstract：:The exchange of metabolites between the mitochondrial matrix and the cytosol depends on β-barrel channels in the outer membrane and α-helical carrier proteins in the inner membrane. The essential translocase of the inner membrane (TIM) chaperones escort these proteins through the intermembrane space, but the structura...

journal_title：Cell

authors： Weinhäupl K,Lindau C,Hessel A,Wang Y,Schütze C,Jores T,Melchionda L,Schönfisch B,Kalbacher H,Bersch B,Rapaport D,Brennich M,Lindorff-Larsen K,Wiedemann N,Schanda P

更新日期：2018-11-15 00:00:00

abstract：:In this issue, Metzis et al., demonstrate that in the development of the central nervous system, patterning along the anterior-posterior axis precedes acquisition of neural identity. This contrasts with the prevailing view that neural identity comes first, providing a new window on the origins of the brain and spinal ...

journal_title：Cell

authors： Simon CS,Hadjantonakis AK

更新日期：2018-11-01 00:00:00

abstract：:Although current immune-checkpoint therapy (ICT) mainly targets lymphoid cells, it is associated with a broader remodeling of the tumor micro-environment. Here, using complementary forms of high-dimensional profiling, we define differences across all hematopoietic cells from syngeneic mouse tumors during unrestrained ...

journal_title：Cell

authors： Gubin MM,Esaulova E,Ward JP,Malkova ON,Runci D,Wong P,Noguchi T,Arthur CD,Meng W,Alspach E,Medrano RFV,Fronick C,Fehlings M,Newell EW,Fulton RS,Sheehan KCF,Oh ST,Schreiber RD,Artyomov MN

更新日期：2018-11-01 00:00:00